ABSTRACT
La dignidad humana es reconocida como uno de los valores de mayor transcendencia para que el ser humano pueda disfrutar de sus derechos. En Colombia a pesar de encontrase regulado dentro de los principios fundamentales de la Constitución Política de 1991 y las normas rectoras de la legislación penal, Ley 600 del año 2000, ese derecho es constantemente violado y no garantizado por el Estado, especialmente en contra de las personas que son cobijadas con medidas de aseguramiento en los centros de reclusiones penitenciarios y carcelarios con los que cuenta el país. Dentro de las causas principales que reflejan la violación de la dignidad humana en las cárceles se destacan;El hacinamiento que se presenta al interior de ellas, donde los reclusos no cuentan con lugares y condiciones dignas, las celdas donde se encuentran recluidos exceden su capacidad, no tienen un espacio y elementos adecuados para su descanso;de igual forma la falta de infraestructuras adecuadas no permite en algunos casos que cuenten con agua limpia para sus necesidades a pesar de ser un servicio esencial para la subsistencia de cualquier ser humano. Con la situación de la pandemia del COVID 19, la problemática carcelaria se ha transmutado a las Unidades de Reacción Inmediatas URI pertenecientes a la Fiscalía General de la Nación y a las Estaciones de Policía, sitios que se han sido designados para la permanencia de aquellas personas a quienes los jueces de la república le imponen una medida de aseguramiento en centro carcelario, lugares que no cuentan con las condiciones mínimas para albergar ese tipo de población.Alternate :Human dignity is recognized as one of the most important values for human beings to enjoy their rights. In Colombia, despite being regulated within the fundamental principles of the Political Constitution of 1991 and the governing norms of criminal legislation, Law 600 of the year 2000, this right is constantly violated and not guaranteed by the State, especially against people who are sheltered with security measures in the penitentiary and prison confinement centers that the country has Among the main causes that reflect the violation of human dignity in prisons stand out;The overcrowding that occurs inside them, where the inmates do not have decent places and conditions, the cells where they are confined exceed their capacity, they do not have adequate space and elements for their rest;In the same way, the lack of adequate infrastructure does not allow them in some cases to have clean water for their needs, despite being an essential service for the subsistence of any human being. With the situation of the COVID 19 pandemic, the prison problem has been transmuted to the URI immediate reaction units belonging to the nation's attorney general's office and to the police stations, places that have been designated for the permanence of those people to who the judges of the republic impose an insurance measure in a prison center, places that do not have the minimum conditions to house this type of population.
ABSTRACT
SARS-CoV-2 primarily infects the respiratory tract, but pulmonary and cardiac complications occur in severe COVID-19. To elucidate molecular mechanisms in the lung and heart, we conducted paired experiments in human stem cell-derived lung alveolar type II (AT2) epithelial cell and cardiac cultures infected with SARS-CoV-2. With CRISPR-Cas9 mediated knock-out of ACE2, we demonstrated that angiotensin converting enzyme 2 (ACE2) was essential for SARS-CoV-2 infection of both cell types but further processing in lung cells required TMPRSS2 while cardiac cells required the endosomal pathway. Host responses were significantly different; transcriptome profiling and phosphoproteomics responses depended strongly on the cell type. We identified several antiviral compounds with distinct antiviral and toxicity profiles in lung AT2 and cardiac cells, highlighting the importance of using several relevant cell types for evaluation of antiviral drugs. Our data provide new insights into rational drug combinations for effective treatment of a virus that affects multiple organ systems.